Table 1 Characteristics of patient hospitalized pneumococcal infections

Male

68.4 (2389)

60.0 (608)

55.2 (556)

 < 0.005

Age, median (IQR), y

71 (60–82)

80 (68–89)

77 (65–88)

 < 0.005

Age groups

 18–59 years

24.4 (852)

12.4 (126)

17.8 (179)

 < 0.005

 60–69 years

23.1 (807)

13.7 (139)

15.9 (160)

 < 0.005

 ≥ 70 years

52.5 (1836)

73.9 (749)

66.4 (669)

 < 0.005

Comorbidity, % (no.)

 Any (at least one)

54.6 (1909)

70.8 (718)

64.0 (645)

 < 0.005

 Diabetes mellitus

14.3 (500)

23.2 (235)

25.3 (255)

 < 0.005

 Liver disease

5.0 (176)

3.9 (40)

5.9 (59)

0.137

 Stroke

11.8 (412)

26.1 (265)

18.0 (181)

 < 0.005

 Malignancy

10.2 (357)

12.6 (128)

12.0 (121)

0.050

 Renal disease

4.9 (173)

9.6 (97)

7.7 (78)

 < 0.005

 Chronic pulmonary disease

14.6 (511)

13.2 (134)

9.9 (100)

 < 0.005

 Congestive heart failure

8.0 (280)

13.5 (137)

12.4 (125)

 < 0.005

 Rheumatological disease

1.9 (67)

1.8 (18)

1.4 (14)

0.540

 HIV infection

0.4 (14)

0.6 (6)

0.6 (6)

0.600

Charlson comorbidity index ≥ 4

53.0 (1852)

75.3 (764)

66.4 (669)

 < 0.005

Type of pneumococcal disease

 IPDWP

7.4 (259)

3.6 (37)

4.4 (44)

 < 0.005

 IPP

12.9 (451)

4.7 (48)

8.0 (81)

 < 0.005

 NIPP

79.7 (2785)

91.6 (929)

87.6 (883)

 < 0.005

Pneumococcal disease by site

 Bacteremia

17.3 (603)

6.8 (69)

10.1 (102)

 < 0.005

 Pneumonia

92.6 (3236)

96.4 (977)

95.6 (964)

 < 0.005

 Pleural empyema

2.2 (78)

1.0 (10)

2.0 (20)

0.040

 Meningitis

1.9 (66)

1.2 (12)

1.4 (14)

0.227

Viral coinfection

 Influenza

8.8 (309)

1.2 (12)

12.1 (122)

 < 0.005

 COVID-19

-

9.0 (91)

10.9 (110)

0.987