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Table 4 Multivariate analysis for assessing capability of different OI in predicting NIRT failure a t0,t12 and t24 according to ROC-related cut off

From: Oxygenation indices and early prediction of outcome in hypoxemic patients with COVID-19 pneumonia requiring noninvasive respiratory support in pulmonary intermediate care unit

Oxygenation indices at t0

ROC cut-off

NIRT failure %

Ref. Categhory

Logistic regression model adjusted for age

Multivariate Analysis*

< cut-off

> cut-off

OR=1

OR

p

95%CI

OR

p

95% CI

PaO2/FiO2 ≤ 200

200

34,2

15,7

>200

2,58

0,001

1,47-4,55

2,14

0,026

1,09-4,17

sPaO2/FiO2 ≤ 159

159

33,1

16,6

>159

2,23

0,005

1,27-3,91

2,01

0,04

1,03-3,93

SpO2/FiO2 ≤ 300

300

34,6

13,8

>300

3,05

<0,0001

1,69-5,52

2,55

0,008

1,28-5,11

a-ADO2>114,4

114,4

14,8

32,4

≤ 114,4

2,63

0,001

1,48-4,69

1,92

0,056

0,98-3,75

adj-a-ADO2D >100,31

100,3

15,7

32,2

≤100,31

2,22

0,006

1,26-3,92

1,78

0,088

0,92-3,46

RI>1,74

1,74

15,5

32,7

≤1,74

2,35

0,003

1,33-4,15

2,17

0,023

1,11-4,23

Oxygenation indices at t12

ROC cut-off

NIRT failure %

Ref. Categhory

Logistic regression model adjusted for age

Multivariate Analysis*

< cut-off

> cut-off

OR=1

OR

p

95%CI

OR

p

95% CI

PaO2FiO2 ≤ 181

181

35,7

12,7

>181

3,01

<0,0001

1,67-5,40

3,67

<0,0001

1,82-7,43

sPaO2/FiO2 ≤ 151,7

151,7

35,3

14,6

>151,7

2,56

0,001

1,45-4,51

3,19

0,001

1,59-6,40

SpO2/FiO2 ≤ 181,5

181,5

28,7

18,2

>181,5

1,55

0,125

0,89-2,71

1,62

0,154

0,83-3,15

a-ADO2>239,5

239,5

17,4

30,5

≤239,5

1,55

0,122

0,80-2,72

1,63

0,146

0,84-3,15

adj-a-ADO2D >214,08

214,1

17,9

29,7

≤214,08

1,56

0,118

0,89-2,73

1,55

0,192

0,80-3,01

RI>2,60

2,6

14,3

35,4

≤2,60

2,68

0,001

1,52-4,75

3,26

0,001

1,62-6,57

Oxygenation indices at t24

ROC cut-off

% of failure

Ref. Categhory

Logistic regression model adjusted for age

Multivariate Analysis*

< cut-off

> cut-off

OR=1

OR

p

95%CI

OR

p

95% CI

PaO2/FiO2 ≤180

180

43,4

8,3

>180

7,2

<0,0001

3,76-13,76

4,94

<0,0001

2,40-10,17

sPaO2/FiO2  ≤ 160,4

160,4

44,4

8,4

>160,4

6,88

<0,0001

3,64-12,99

5,89

<0,0001

2,82-12,30

SpO2/FiO2 ≤ 192,1

192,1

31,1

16,2

>192,1

2,39

0,005

1,29-4,04

1,69

0,124

0,87-3,29

a-ADO2>220,7

220,7

14,6

34,6

≤220,7

2,79

<0,0001

1,57-4,95

2,24

0,011

1,22-4,65

adj-a-ADO2D >186,26

186,3

13,8

33,5

≤186,26

3,09

<0,0001

1,71-5,57

2,35

0,016

1,17-4,71

RI>2,37

2,37

8,7

42,0

≤2,37

6,25

<0,0001

3,30-11,85

4,5

<0,0001

2,18-9,30

  1. sPaO2/FiO2 standardized PaO2/FiO2 ratio, a-ADO2 alveolar-arterial oxygen gradient, adj-a-ADO2D_ alveolar-arterial oxygen gradient adjusted for age, RI Respiratory Index, NIRT non invasive respiratory therapies, t0 baseline, t12 after 12 hours of NIRT, t24 after 24 hours of NIRT
  2. *Multivariate logistic regression analysis for each OI adjusted for sex, age, confusion state, Charlson index , neurologic comorbidities, pronation, sedation
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