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Table 2 Comparison by univariate and multivariate analysis of deceased and surviving patients

From: Epidemiology, clinical and biological characteristics, and prognosis of critically ill COVID 19 patients: a single-center experience through 4 successive waves

 

Alive (N = 384)

Deceased (N = 53)

p-value

Multivariate analysis OR (95%IC) p-value

Characteristics

 Age, years, median (Q1;Q3)

64 (55;72)

71 (66;77)

< 0.001

1.09 (1.04;1.15), p = 0.001

 Smoking, n (%)

84 (22%)

16 (31%)

NS

-

 Coronary artery disease, n (%)

36 (9%)

15 (29%)

0.001

-

 Hypertension, n (%)

158 (41%)

31 (60%)

0.013

-

 Chronic kidney disease, n (%)

26 (7%)

13 (25%)

< 0.001

-

 Diabete mellitus, n (%)

38 (10%)

10 (19%)

0.048

-

 Chronic pulmonary disease, n (%)

76 (20%)

18 (35%)

0.0165

-

 Charlson score, median (Q1;Q3)

1 (0;2)

2 (1;5)

< 0.001

1.23 (1.02;1.48), p = 0.028

ICU admission

 SAPS II, median (Q1;Q3)

31 (21;42)

49 (40;63)

< 0.001

-

 SOFA score, median (Q1;Q3)

3 (2;7)

8 (6;10)

< 0.001

1.40 (1.19;1.66), p < 0.001

 PaO2/FiO2 ratio, median (Q1;Q3)

150 (110;188)

130 (90;168)

0,039

-

 CRP, mg/L, median (Q1;Q3)

140 (81.2;212.5)

173.4 (121.5;258.4)

0.0337

-

 Lactates, mmol/L, median (Q1;Q3)

1.2 (1;1.6)

1.6 (1.2;2)

< 0.001

1.61 (1.15;2.40), p = 0.011

 D-dimer, ng/mL, median (Q1;Q3)

943 (573;1739)

1447 (811;4000)

0.0066

-

 Lymphocytes 109/L, median (Q1;Q3)

0.71 (0.52;0.93)

0.585 (0.4;0.76)

0.0273

-

ICU stay

 MV, n (%)

236 (61%)

46 (87%)

< 0.001

-

 Delay admission-MV, days, median (Q1;Q3)

0;1 (0)

0 (0;1)

NS

-

 Prone position, n (%)

127 (33%)

35 (66%)

< 0.001

4.25 (1.62;12.65),.p = 0.005

 Duration of MV, days, median (Q1;Q3)

9 (5;19)

11 (5;26)

NS

-

 Vasopressorsa, n (%)

29 (8%)

19 (36%)

< 0.001

-

 AKI, n (%)

106 (28%)

29 (56%)

< 0.001

-

 Dexamethasone, n (%)

322 (84%)

35 (66%)

0.0022

-

 RRT, n (%)

29 (8%)

25 (47%)

< 0.001

-

 ICU LOS, days, median (Q1;Q3)

8 (4;14.3)

9 (5;20)

NS

-

  1. SAPSII simplified acute physiologic score, SOFA sequential organ failure assessment, MV mechanical ventilation, AKI acute kidney injury, VAP ventilated associated pneumonia, CAPA Covid19 associated pulmonary aspergillosis, RRT renal replacement therapy, LOS length of stay, ICU intensive care unit
  2. anorepinephrine > 0.3µg/kg/min