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Table 2 Demographic data of patients with or without invasive pulmonary aspergillosis infection

From: Invasive pulmonary aspergillosis among patients with severe community-acquired pneumonia and influenza in ICUs: a retrospective cohort study

 

Severe CAP, n  = 252

Severe influenza, n  = 59

With IPA

n  = 24

Without IPA

n  = 228

p -value

With IPA

n  = 9

Without IPA

n  = 50

p -value

Age, mean ± SD

74.58 ± 12.18

71.67 ± 14.43

0.341

60.98 ± 11.58

71.93 ± 17.42

0.152

Gender, n (%)

  

0.874

  

0.033*

 Male

17 (70.8%)

148 (58.7%)

 

8 (88.9%)

21 (42%)

 

 Female

7 (29.2%)

80 (413%)

 

1 (11.1%)

29 (58%)

 

BMI (kg/m2)

21.3 ± 5.2

22.47 ± 4.84

0.264

21.96 ± 3.29

25.02 ± 4.90

0.077

APACHE II score, mean ± SD

23.63 ± 5.45

20.16 ± 6.18

0.009*

17.44 ± 3.71

18.78 ± 5.898

0.516

Use of MV, N (%)

24 (100%)

224(98.2%)

0.466

8 (88.9%)

46(92%)

0.763

Use of ECMO, N (%)

0 (0%)

1 (0.4%)

0.746

2 (22%)

2 (4%)

0.256

ARDS

18 (75%)

128 (56%)

0.59

4 (44%)

24 (48%)

0.847

Acute kidney injury

17 (71%)

126 (55%)

0.132

1 (11%)

13 (26%)

0.263

Thromboembolism events

2(8%)

14(6%)

0.677

1(11%)

9(18%)

0.619

MV days (Mean ± SD)

27.88 ± 22.54

19.40 ± 18.67

0.039*

11.78 ± 7.29

20.66 ± 20.94

0.026*

ICU days (Mean ± SD)

29.79 ± 22.01

18.09 ± 11.69

0.017*

14.22 ± 6.2

16.68 ± 9.90

0.476

Hospital days (Mean ± SD)

40.04 ± 30.55

34.86 ± 27.90

0.391

18.44 ± 7.78

33.54 ± 22.93

0.001*

28-day mortality, N (%

10 (42%)

44 (19%)

0.045*

6 (67%)

5 (10%)

0.009*

ICU mortality, N (%)

10 (42%)

53 (23%)

0.095

6 (67%)

6 (12%)

0.011*

90-day mortality, N (%)

12 (50%)

75 (33%)

0.094

6 (67%)

8 (16%)

0.016*

Co-morbidities, N (%)

 Cardiovascular history

10 (42%)

68 (30%)

0.234

1 (11%)

12 (24%)

0.327

 Hypertension

11 (46%)

112 (49%)

0.760

4 (44%)

28 (56%)

0.530

 COPD

5 (21%)

25 (11%)

0.270

4 (44%)

3 (6%)

0.062

 Asthma

2 (8%)

7 (3%)

0.379

0 (0%)

1 (2%)

0.675

 ICS 28 days before ICU

3 (13%)

7 (3%)

0.190

1 (11%)

1 (2%)

0.442

 OCS 28 days before ICU

2 (8%)

7 (3%)

0.379

0 (0%)

0 (0%)

1.000

 TB

1 (4%)

7 (3%)

0.772

0 (0%)

1 (2%)

0.675

 Liver cirrhosis

4 (17%)

23 (10%)

0.324

1 (11%)

6 (12%)

0.941

 Diabetes mellitus

9 (37%)

78 (34%)

0.748

5 (56%)

20 (40%)

0.552

 Chronic kidney disease

3 (12%)

24 (10%)

0.767

2 (22%)

7 (14%)

0.536

 Advanced cancer malignancy

5 (21%)

28 (12%)

0.337

1 (11%)

2 (4%)

0.380

 Autoimmune disease

0 (0%)

11 (5%)

0.001*

0 (0%)

0 (0%)

1.000

 AIDS

0 (0%)

1 (0.4%)

0.629

0 (0%)

0 (0%)

1.000

  1. CAP community acquired pneumonia, BMI body mass index, APACHE II Acute Physiology and Chronic Health Evaluation II score, ARDS acute respiratory distress syndrome, ECMO Extracorporeal Membrane Oxygenation, MV mechanical ventilation, COPD chronic obstructive pulmonary disease, ICS inhaled corticosteroid, OCS oral corticosteroid, TB tuberculosis, AIDS Acquired immunodeficiency syndrome
  2. *P < 0.05, Chi-Square test, Mann–Whitney U test
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