Table 1 Demographic data of patients with severe community-acquired pneumonitis or severe influenza infection in the ICUs

Gender (M/F)

165/87

29/30

0.157

Age (year, Mean ± SD)

71.94 ± 14.24

62.32 ± 16.88

< 0.001^*

BMI (Mean ± SD)

22.36 ± 4.88

24.55 ± 4.80

0.002^*

APACHI II score (Mean ± SD)

20.49 ± 6.19

18.58 ± 5.62

0.003^*

Use of MV, N (%)

247 (98%)

54(91.5%)

0.089

Use of ECMO, N (%)

1 (0.4%)

4 (7%)

0.06

ARDS

146 (58%)

28 (47%)

0.145

Acute kidney injury

143 (57%)

14 (24%)

< 0.001^*

Thromboembolism events

16(6%)

10(17%)

0.044^*

Invasive pulmonary aspergillosis, N (%)

24 (9.5%)

9 (15.3%)

0.262

 - Proven, N

4

4

 - Probable, N

20

5

 - GM > 1 on BALF alone, N

19

7

 - GM > 0.5 on serum alone, N

1

0

 - GM positive of both BALF and serum, N

4

2

- BALF GM Threshold OD(Mean ± SD)

3.78 ± 1.98

4.02 ± 2.02

  1–1.5, N

4

1

  1.5–3, N

5

2

  > 3, N

14

6

MV days (Mean ± SD)

20.21 ± 19.18

19.31 ± 19.7

0.747

ICU days (Mean ± SD)

19.21 ± 13.4

16.31 ± 9.43

0.054

Hospital days (Mean ± SD)

35.35 ± 28.14

31.24 ± 21.97

0.295

28-day mortality, N (%)

54 (21%)

12 (20%)

0.637

ICU mortality, N (%)

63 (25%)

11 (19%)

0.453

90-day mortality, N (%)

87(35%)

14 (24%)

0.092

Co-morbidities, N (%)

 Cardiovascular history

78 (31%)

13 (22%)

0.152

 Hypertension

123 (49%)

32 (54%)

0.455

 COPD

30 (12%)

7 (12%)

0.985

 Asthma

9 (4%)

1 (2%)

0.464

 ICS 28 days before ICU

10 (4%)

2 (3%)

0.836

 OCS 28 days before ICU

9 (4%)

0 (0%)

0.003^*

 TB

8 (3%)

1 (2%)

0.543

 Liver cirrhosis

27 (11%)

7 (12%)

0.800

 Diabetes mellitus

87 (35%)

25 (42%)

0.301

 Chronic kidney disease

27 (11%)

9 (15%)

0.328

 Advanced cancer malignancy

33 (13%)

3 (5%)

0.027^*

 Autoimmune disease

11 (4%)

0 (0%)

0.001^*

 AIDS

1 (0.4%)

0 (0%)

0.629